4、严重不良事件（Serious Adverse Event）:指在任何剂量时发生的非预期的以下临床事件：死亡；危及生命；需要住院治疗或延长目前的住院治疗时间；导致持续的或显著的功能丧...
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serious adverse event sae 严重不良事件
Serious Adverse Event Reporting 严重不良事件报告
serious adverse drug event 严重药物不良事件
No patients had serious adverse event.
无一患者出现严重不良反应。
The only serious adverse event was seen in a patient in the quinine group who developed fatal black water fever.
唯一的严重不利事件是奎宁组中有一名患者罹患了致命的黑尿热。
As well, no definitive serious adverse event reports of distant spread of toxin effect have been associated with Botox when used at approved doses for eyelid twitches or for crossed eyes.
并且，当使用Botox已批准的剂量用于治疗眼皮痉挛或“斗鸡眼”(crossed eyes)时亦未见因毒素作用远端扩散而导致的最终严重不良事件报道。
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